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KMID : 0358419760190030197
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Korean Journal of Obstetrics and Gynecology
1976 Volume.19 No. 3 p.197 ~ p.206
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Determination of maternal serum alpha fetoprotein by radioimmunoassay during pregnancy and postpartum
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고영우/Koh YW
장윤석/Chang YS
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Abstract
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Alpha fetoprotein of the maternal serum was determined by radioimmunoassay in 20 cases of non-pregnant women, and in 151 sera from 144 women at different stages of pregnancy and 15 sera from 14 women after delivery. Serum Alpha fetoprotein concentration in Korean women was in a range of 0 to 20 ng. per mililiter. The initial increase of serum Alpha fetoprotein was noted after 11 th week of gestation. subsequently the serum Alpha fetoprotein level increased to reach its maximum level approximately 36th to 38th week of gestation. The maximum level of serum Alpha fetoprotein determined in the present study was 497ng. per mililiter at 36 th week of gestation. At term pregnancy it leveled off slightly. during the first trimester, the Alpha fetoprotein level ranged from 29 to 125ng. per mililiter; and during the third trimester, from 96 to 497 ng. per mililiter . At labor the maternal serum Alpha fetoprotein level ranged from 67 to 286 ng per mililiter. The serum Alpha fetoprotein level decreased rapidly following delivery and was almost returned to the normal level by 12 th postpartum day.
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